Author

A. L. Pey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Approach:statistical model· 2 Assay:structural biology· 2 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Grieco· 2 shared J. M. Martin Garcia· 2 shared M. Medina· 2 shared A. Ansari· 1 shared A. Manna· 1 shared A. P. Mancuso· 1 shared A. Ros· 1 shared A. Round· 1 shared

Activity by Year

2022-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersBiochemistry

A. Grieco

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Author profile →

4 papers

Recent·Most cited

Engineered Oxalate decarboxylase boosts activity and stability for biological applications

M. Dindo, C. Conter, G.-I. Uechi, G. Pampalone, L. Ruta, A. L. Pey, L. Rossi, P. Laurino, M. Magnani, B. Cellini

This study engineers Oxalate decarboxylase to improve its activity and stability for medical applications in hyperoxaluria treatment.

bioRxiv · May 6, 2024Biochemistry

Minimized Sample Consumption for Time-Resolved Serial Crystallography Applied to the Redox Cycle of Human NQO1

D. Doppler, A. Grieco, D. Koh, A. Manna, A. Ansari, R. Alvarez, K. Karpos, H. Le, M. Sonker, G. Ketawala, S. Mahmud, I. Quereda Moraleda, A. L. Pey, R. Letrun, K. Doerner, , A. Ros

This paper demonstrates a method to reduce sample consumption in time-resolved serial crystallography by using segmented droplet generation and mix-and-inject approaches for studying NQO1's redox cycle.

bioRxiv · Apr 29, 2024Biochemistry

Structural dynamics and functional cooperativity of human NQO1 by ambient temperature serial crystallography and simulations

A. Grieco, S. Boneta, J. A. Gavira, A. L. Pey, S. Basu, J. Orlans, D. de Sanctis, M. Medina, J. M. Martin Garcia

This study determines the structure of hNQO1 with NADH using serial crystallography and simulations, showing NADH binding stabilizes the protein and drives functional cooperativity through structural communication.

Protein Science · Mar 19, 2024Peer-reviewedBiochemistry

Effect of naturally-occurring mutations on the stability and function of cancer-associated NQO1: comparison of experiments and computation.

J. L. Pacheco-Garcia, M. Cagiada, K. Tienne-Matos, E. Salido, K. Lindorff-Larsen, A. L. Pey

The paper compares computational predictions and experimental analysis of NQO1 variants to assess their stability and function, finding good correlation but noting outliers.

bioRxiv · Sep 30, 2022Biophysics