Author

J. M. Vanegas

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Biophysics· 2

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Anishkin· 1 shared A. Sharma· 1 shared R. R. Tatikonda· 1 shared S. I. Sukharev· 1 shared S. Sukharev· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 4 mutual co-author links

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1 shared paperBiophysics

A. Anishkin

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2 papers

Recent·Most cited

Tight hydrophobic core and flexible helices yield MscL with a high tension gating threshold and a membrane area mechanical strain buffer

A. Sharma, A. Sharma, S. Sukharev, J. M. Vanegas

This paper uses atomistic simulations to show that WT TbMscL expands without breaking its hydrophobic seal, while GOF mutants open quickly due to solvation of the de-wetted constriction.

bioRxiv · Feb 25, 2023 · PreprintBiophysics

Mechanical Activation of MscL Revealed by a Locally Distributed Tension Molecular Dynamics Approach

R. R. Tatikonda, A. Anishkin, S. I. Sukharev, J. M. Vanegas

This paper introduces a new molecular dynamics method to simulate the mechanical activation of MscL, showing reproducible and reversible transitions to the open state with experimentally accurate parameters.

bioRxiv · Aug 19, 2020Biophysics