S. Sukharev

The dynamic hypoosmotic response of Vibrio cholerae relies on the mechanosensitive channel MscS

This study investigates the role of MscS and MscL channels in Vibrio cholerae's hypoosmotic response, showing MscS is critical for osmolyte release and survival.

MscS inactivation and recovery are slow voltage-dependent processes sensitive to interactions with lipids

This study investigates the voltage-dependent inactivation and recovery of MscS channels, showing that lipid-protein interactions significantly influence these processes.

Tight hydrophobic core and flexible helices yield MscL with a high tension gating threshold and a membrane area mechanical strain buffer

This paper uses atomistic simulations to show that WT TbMscL expands without breaking its hydrophobic seal, while GOF mutants open quickly due to solvation of the de-wetted constriction.

A novel mechanosensitive channel controls osmoregulation, differentiation and infectivity in Trypanosoma cruzi

This study identifies and characterizes TcMscS, a mechanosensitive channel in Trypanosoma cruzi, showing its role in osmoregulation, differentiation, and infectivity.

Dissipation During the Gating Cycle of the Bacterial Mechanosensitive Ion Channel Approaches the Landauer's Limit

The paper shows that the bacterial mechanosensitive ion channel MscS dissipates energy close to the Landauer's limit during its gating cycle.

Recovery of equilibrium free energy from non-equilibrium thermodynamics with mechanosensitive ion channels in E. coli

The paper develops a method to calculate the equilibrium free energy difference of mechanosensitive ion channels from non-equilibrium measurements in E. coli.

Spatiotemporal relationships defining the adaptive gating of the bacterial mechanosensitive channel MscS

This study analyzes the tension-dependent gating mechanism of MscS channels using a Markov model to quantify their adaptive inactivation behavior under different tension conditions.