A. Anishkin

Turgor and the conformational pathway for MscS recovery

This paper models the conformational transition of MscS from a splayed state to a compact closed state, driven by turgor pressure and lipid synthesis, revealing a recovery mechanism for MscS-like channels.

The lipid-mediated mechanism of mechanosensitive channel MscS inactivation

This study identifies a lipid-mediated mechanism by which the mechanosensitive channel MscS inactivates, showing that intercalated lipids physically decouple tension-sensing helices from the gate.

The dynamic hypoosmotic response of Vibrio cholerae relies on the mechanosensitive channel MscS

This study investigates the role of MscS and MscL channels in Vibrio cholerae's hypoosmotic response, showing MscS is critical for osmolyte release and survival.

MscS inactivation and recovery are slow voltage-dependent processes sensitive to interactions with lipids

This study investigates the voltage-dependent inactivation and recovery of MscS channels, showing that lipid-protein interactions significantly influence these processes.

Mechanosensitive channel MscS is critical for termination of the bacterial hypoosmotic permeability response

The paper shows that MscS is critical for terminating the bacterial hypoosmotic permeability response by inactivating MscL, ensuring proper membrane tension regulation.

A novel mechanosensitive channel controls osmoregulation, differentiation and infectivity in Trypanosoma cruzi

This study identifies and characterizes TcMscS, a mechanosensitive channel in Trypanosoma cruzi, showing its role in osmoregulation, differentiation, and infectivity.

Mechanical Activation of MscL Revealed by a Locally Distributed Tension Molecular Dynamics Approach

This paper introduces a new molecular dynamics method to simulate the mechanical activation of MscL, showing reproducible and reversible transitions to the open state with experimentally accurate parameters.