S. I. Sukharev

Turgor and the conformational pathway for MscS recovery

This paper models the conformational transition of MscS from a splayed state to a compact closed state, driven by turgor pressure and lipid synthesis, revealing a recovery mechanism for MscS-like channels.

On the lipid dependence of bacterial mechanosensitive channel gating in situ

This study investigates how different lipid species affect the function of mechanosensitive channels in E. coli, finding that cardiolipin is important for MscS adaptive behavior.

The lipid-mediated mechanism of mechanosensitive channel MscS inactivation

This study identifies a lipid-mediated mechanism by which the mechanosensitive channel MscS inactivates, showing that intercalated lipids physically decouple tension-sensing helices from the gate.

Mechanosensitive channel MscS is critical for termination of the bacterial hypoosmotic permeability response

The paper shows that MscS is critical for terminating the bacterial hypoosmotic permeability response by inactivating MscL, ensuring proper membrane tension regulation.

Mechanical Activation of MscL Revealed by a Locally Distributed Tension Molecular Dynamics Approach

This paper introduces a new molecular dynamics method to simulate the mechanical activation of MscL, showing reproducible and reversible transitions to the open state with experimentally accurate parameters.