J. Mansfeld

A ROS-dependent mechanism to drive progression through S phase

This study identifies a ROS-dependent mechanism that regulates CDK2 activity and cell cycle progression by modulating T-loop phosphorylation.

UFMylation regulates translational homeostasis and cell cycle progression

This study shows UFMylation regulates translation and cell cycle progression by controlling eIF4F complex assembly and ribosome recruitment, independent of stress response pathways.

Degron-tagged reporters probe membrane topologyand enable the specific labelling of membrane-wrapped structures

The paper introduces degron-tagged reporters to specifically label and track membrane-wrapped structures, enabling visualization of organelles and cell debris in various organisms.

An E2-ubiquitin thioester-driven approach to identify substrates modified with ubiquitin and ubiquitin-like molecules

This paper introduces E2~dID, a method to identify substrates modified by ubiquitin and ubiquitin-like molecules using E2-thioester conjugates, validated in human and yeast systems.

Conditional control of fluorescent protein degradation by an auxin-dependent nanobody

This paper develops an AID-nanobody system for conditional and reversible degradation of GFP-tagged proteins in human cells and zebrafish, demonstrating its use on APC/C.

Regulation of mitochondrial dynamics by Aurora A kinase

This study shows that Aurora A kinase associates with mitochondria and influences their dynamics, affecting mitochondrial morphology in different cell lines.