Author

T. I. Roumeliotis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 2 Immunology· 1 Microbiology· 1

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Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Organism:human· 5 Assay:proteomics· 5 Approach:statistical model· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Assay:imaging· 2

Frequent Co-Authors

J. S. Choudhary· 3 shared G. Bakos· 2 shared I. A. Gak· 2 shared J. Choudhary· 2 shared J. Mansfeld· 2 shared J. S. Chaudhary· 2 shared L. Yu· 2 shared A. Abubacar· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersCell Biology

J. S. Choudhary

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Author profile →

7 papers

Recent·Most cited

Spatial control of the APC/C ensures the rapid degradation of Cyclin B1

L. Cirillo, R. Young, S. Veerapathiran, A. Roberti, M. S. Martin, A. Abubacar, C. Perosa, C. Coates, R. Muhammad, T. I. Roumeliotis, J. Choudhary, C. Alfieri, J. Pines

The paper shows that spatial regulation of the APC/C at mitotic chromosomes enables rapid Cyclin B1 degradation, ensuring proper cell division and genomic stability.

bioRxiv · Oct 26, 2023Cell Biology

Coupling of Nuclear Translocation to Cell Size Promotes Robustness to Fluctuations in YAP/TAZ Concentration

I. Jones, M. A. Garcia, P. P. Vargas, M. Beykou, L. G. Dent, T. Choudhary, T. I. Roumeliotis, J. S. Chaudhary, J. E. Sero, C. Bakal

The paper shows that nuclear YAP/TAZ concentration remains stable during cell cycle despite whole-cell dilution, due to coupling with cell size and nuclear transport processes.

bioRxiv · Feb 6, 2023Cell Biology

HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation

L. Pearl, J. Oberoi, X. Aran-Guiu, E. A. Outwin, P. Schellenberger, T. I. Roumeliotis, J. S. Chaudhary

The paper presents cryoEM structures of HSP90-CDC37-BRAFV600E complexes with PP5, showing how PP5 dephosphorylates client kinases upon recruitment to HSP90 complexes.

bioRxiv · May 3, 2022Biochemistry

Transcriptome-wide identification of coding and noncoding RNA-binding proteins defines the comprehensive RNA interactome of Leishmania mexicana

K. Kalesh, W. Wei, B. S. Mantilla, T. I. Roumeliotis, J. Choudhary, P. W. Denny

This study identifies 2,417 RNA-binding proteins in Leishmania mexicana, including novel non-poly(A)-RNA-binding proteins, and reveals their roles in RNA-protein interactions and regulation of the protein kinome.

bioRxiv · Dec 8, 2021Microbiology

UFMylation regulates translational homeostasis and cell cycle progression

I. A. Gak, D. Vasiljevic, T. Zerjatke, L. Yu, M. Brosch, T. I. Roumeliotis, C. Horenburg, N. Klemm, G. Bakos, A. Herrmann, J. Hampe, I. Glauche, J. S. Choudhary, J. Mansfeld

This study shows UFMylation regulates translation and cell cycle progression by controlling eIF4F complex assembly and ribosome recruitment, independent of stress response pathways.

bioRxiv · Feb 3, 2020 · PreprintCell Biology

Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines

E. C. Gamez, B. Soskic, T. I. Roumeliotis, E. So, D. J. Smyth, M. Baldrighi, D. Wille, N. Nakic, J. Esparza-Gordillo, C. G. C. Larminie, P. G. Bronson, D. F. Tough, W. C. Rowan, J. S. Choudhary, G. Trynka

The paper uses single-cell RNA-seq and other methods to show that CD4+ T cells form an effectorness gradient, with cytokine responses varying along this continuum.

bioRxiv · Sep 4, 2019Immunology

An E2-ubiquitin thioester-driven approach to identify substrates modified with ubiquitin and ubiquitin-like molecules

G. Bakos, L. Yu, I. A. Gak, T. I. Roumeliotis, D. Liakopoulos, J. S. Choudhary, J. Mansfeld

This paper introduces E2~dID, a method to identify substrates modified by ubiquitin and ubiquitin-like molecules using E2-thioester conjugates, validated in human and yeast systems.

bioRxiv · Oct 10, 2018Biochemistry