Pseudomonas aeruginosa Elicits Sustained IL-1β Upregulation in Alveolar Macrophages from Lung Transplant Recipients
N. Britton, A. V. Rueda, S. A. Whiteside, J. Mathew, M. Kelley, S. Agbor-Enoh, J. McDyer, J. D. Christie, R. G. Collman, A. Cox, P. Shah, F. D'Alessio
This study shows that Pseudomonas aeruginosa and its dominant microbiota increase IL-1β production in alveolar macrophages from lung transplant recipients, which can be reduced by inflammasome inhibitors.
bioRxiv · Apr 26, 2022 · PreprintImmunology