P. Shah

Integrating molecular and clinical variables to predict myocardial recovery

This study integrates clinical and transcriptomic data to predict myocardial recovery in heart failure patients after LVAD implantation, identifying 80 features with an AUC of 0.731.

CDK12 Loss Promotes Prostate Cancer Development While Exposing Vulnerabilities to Paralog-Based Synthetic Lethality

This study shows CDK12 loss drives prostate cancer development and identifies CDK13 as a therapeutic target through paralog-based synthetic lethality in CDK12-mutant tumors.

Massively parallel base editing screens to map variant effects on anti-tumor hallmarks of primary human T cells

This study uses base editing to screen for variants affecting T cell anti-tumor functions, identifying mutations that enhance tumor elimination with minimal off-target effects.

Ultra-Long-Term Delivery of Hydrophilic Drugs Using Injectable In Situ Cross-Linked Depots

This paper develops an injectable platform for ultra-long-term hydrophilic drug delivery, achieving sustained release over six months in vivo.

A Drug-Free Pathogen Capture and Neutralizing Nasal Spray to Prevent Emerging Respiratory Infections

This paper introduces a drug-free nasal spray that captures and neutralizes respiratory pathogens, showing high efficacy in mice against influenza.

A new vulnerability to BET inhibition due to enhanced autophagy in BRCA2 deficient pancreatic cancer

This study identifies BET inhibition as a potential therapy for BRCA2-deficient pancreatic cancer by showing it enhances autophagy-dependent cell death in these cells.

Topographical analysis of immune cell interactions reveals a biomechanical signature for immune cytolysis

The paper analyzes immune cell interactions using traction force microscopy to identify biomechanical features associated with cytotoxic T cell activity.

Intestinal transit amplifying cells require METTL3 for growth factor signaling, KRAS expression, and cell survival

This study shows METTL3 is essential for survival of intestinal transit amplifying cells, maintaining growth factor signaling and KRAS expression, and its deletion leads to intestinal atrophy and death.

Linking genotypic and phenotypic changes in the E. coli Long-Term Evolution Experimentusing metabolomics

The paper links mutations to metabolic changes and fitness in E. coli from the LTEE using metabolomics and integrates this with mutation and expression data.

OpenMEA: Open-Source Microelectrode Array Platform for Bioelectronic Interfacing

This paper introduces OpenMEA, an open-source platform for closed-loop bioelectronics research, enabling in vitro studies of bioelectronic interfaces with human and rodent brain slices.

Quantitative bioactivity signatures of dietary supplements and natural products

The paper screens dietary supplements and natural products for bioactivity using in vitro assays and predicts their mechanisms of action by comparing activity profiles with approved drugs.

Low lamin A levels enhance confined cell migration and metastatic capacity in breast cancer

This study shows that low lamin A levels in breast cancer cells increase nuclear deformability and metastatic capacity, with lower lamin A levels linked to poorer disease-free survival in human tumors.

Pseudomonas aeruginosa Elicits Sustained IL-1β Upregulation in Alveolar Macrophages from Lung Transplant Recipients

This study shows that Pseudomonas aeruginosa and its dominant microbiota increase IL-1β production in alveolar macrophages from lung transplant recipients, which can be reduced by inflammasome inhibitors.

PME-1 suppresses anoikis, and is associated with therapy relapse of PTEN-deficient prostate cancers

This study identifies PME-1 as a biomarker for aggressive PTEN-deficient prostate cancers by showing its role in suppressing anoikis.

ATM modulates nuclear mechanics by regulating lamin A levels

This study shows ATM regulates lamin A levels, affecting nuclear mechanics and cell migration.

Preclinical Pharmacokinetics and In Vitro Properties of GS-441524, A Potential Oral Drug Candidate for COVID-19 Treatment

This study examines the preclinical pharmacokinetics and in vitro ADME properties of GS-441524, showing its stability across species and varying bioavailability, supporting its development as an oral drug candidate for COVID-19.

Polyamines and eIF5A hypusination facilitate SREBP2 translation and cholesterol synthesis to enhance enterovirus attachment and infection

This study shows polyamines enhance CVB3 infection by promoting SREBP2 translation and cholesterol synthesis, linking polyamine and cholesterol homeostasis.

Intragenomic variation in mutation biases causes underestimation of selection on synonymous codon usage

The paper assesses how intragenomic variation in mutation bias affects estimates of selection on synonymous codon usage in yeast, finding that ignoring this variation can underestimate selection signals.

SARS-Cov-2 Spike binding to ACE2 is stronger and longer ranged due to glycan interaction

The paper uses molecular dynamics simulations to show that glycosylation enhances the binding strength and range of SARS-CoV-2 Spike to ACE2 through glycan-mediated interactions.

Thiophenesulfonamides are specific inhibitors of quorum sensing in pathogenic Vibrios

The paper identifies thiophenesulfonamides as specific inhibitors of quorum sensing in Vibrio species, with PTSP showing potent activity against multiple strains.

Promoter-sequence determinants and structural basis of primer-dependent transcription initiation in Escherichia coli

The paper identifies promoter sequence determinants and structural basis of primer-dependent transcription initiation in E. coli using MASTER and biochemical studies.

Nuclear deformation causes DNA damage by increasing replication stress

The paper shows that nuclear deformation during migration or compression causes DNA damage by increasing replication stress, primarily in S/G2 phase, independent of nuclear envelope rupture.

The landscape of transcriptional and translational changes over 22 years of bacterial adaptation

This study examines transcriptional and translational changes in E. coli over 22 years of adaptation, finding that mRNA abundance increases with cell size and that gene expression patterns are similar across replicate populations despite few shared mutations.

Implantable photonic neural probes for light-sheet fluorescence brain imaging

The paper introduces implantable photonic neural probes that enable light-sheet fluorescence imaging in brain tissues without additional micro-optic components.

Epidemiology of Dengue viral infection in Nepal: 2006-2019

This study analyzes dengue incidence trends and spatio-temporal patterns in Nepal from 2006-2019, finding increased risk in lowland regions and rising spread to mid-mountains.

Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient

This paper identifies an antibody, EY6A, from a convalescent patient that neutralizes SARS-CoV-2 and cross-reacts with SARS-CoV-1 by binding a conserved epitope on the Spike protein.

Ubiquilin proteins regulate EGFR levels and activity in lung adenocarcinoma cells

This study shows that UBQLN1 regulates EGFR levels and activity in lung adenocarcinoma cells, affecting proliferation, migration, and invasion.

UBR-Box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic target

This study shows UBR5 is over-expressed in lung adenocarcinoma and its loss reduces cell viability and tumor growth, suggesting it as a therapeutic target.

Ripasudil in a model of pigmentary glaucoma

This study evaluates Ripasudil's effects on pigmentary glaucoma in a porcine model, showing reduced trabecular meshwork stress fibers, restored phagocytosis, and normalized intraocular pressure.

Comparative analysis of genome-wide DNA methylation identifies patterns that associate with conserved transcriptional programs in osteosarcoma

This study identifies DNA methylation patterns in human and canine osteosarcoma samples that correlate with conserved transcriptional programs and tumor states, not cell composition.