Dynamic control of metabolic zonation and liver repair by endothelial cell Wnt2 and Wnt9b revealed by single cell spatial transcriptomics using Molecular Cartography
S. Hu, S. Liu, B. Yu, M. Poddar, S. Singh, C. Cao, J. McGaughey, A. Bell, L. L. Blazer, J. Adams, S. Sidhu, S. Angers, S. P. Monga
This study identifies endothelial cell Wnt2 and Wnt9b as key regulators of liver zonation and repair, showing their therapeutic potential in acute liver failure using single-cell spatial transcriptomics.
bioRxiv · Mar 18, 2022Pathology