Author

J. N. Mahale

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Biology Disciplines

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Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

A. Gerard· 1 shared A. J. He· 1 shared A. J. MacLean· 1 shared D. Lau· 1 shared H. Cai· 1 shared J. M. Mazet· 1 shared L. F. K. Uhl· 1 shared T. Elliott· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperImmunology

A. Gerard

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1 paper

Recent·Most cited

Integration of Avidity and Differentiation is enabled by CD8+ T-cell sensing of IFN-γ

L. F. K. Uhl, H. Cai, J. N. Mahale, A. J. MacLean, J. M. Mazet, A. J. He, D. Lau, T. Elliott, A. Gerard

This study shows that CD8+ T-cells sense IFN-γ to coordinate T-cell affinity and differentiation during infection, enhancing memory response avidity but reducing primary response avidity.

bioRxiv · Mar 6, 2023Immunology