ImmunologybioRxiv
Integration of Avidity and Differentiation is enabled by CD8+ T-cell sensing of IFN-γ
L. F. K. Uhl, H. Cai, J. N. Mahale…·A. Gerard
This study shows that CD8+ T-cells sense IFN-γ to coordinate T-cell affinity and differentiation during infection, enhancing memory response avidity but reducing primary response avidity.
DOI 10.1038/s41467-023-42455-4