T. Elliott

Single-cell immune multi-omics and repertoire analyses in pancreatic ductal adenocarcinoma reveal differential immunosuppressive mechanisms within different tumour microenvironments

The paper analyzes single-cell immune multi-omics data from PDAC to identify differential immunosuppressive mechanisms in distinct tumour microenvironments.

Integration of Avidity and Differentiation is enabled by CD8+ T-cell sensing of IFN-γ

This study shows that CD8+ T-cells sense IFN-γ to coordinate T-cell affinity and differentiation during infection, enhancing memory response avidity but reducing primary response avidity.

Identification of neoantigens in esophageal adenocarcinoma

This study identifies neoantigens in esophageal adenocarcinoma, finding one directly presented HLA-I neoantigen and a predicted HLA-II neoantigen with T-cell responses, highlighting challenges in neoantigen detection.

Immunopeptidomic analysis of influenza A virus infected human tissues identifies internal proteins as a rich source of HLA ligands

Fluctuations in TCR and pMHC interactions regulate T cell activation

This study introduces a stochastic model of T cell activation showing that information from TCR-pMHC interactions, not binding strength, drives immune responses and suggests optimizing stochasticity could improve therapeutics.

Protective low avidity anti-tumour CD8+ T cells are selectively attenuated by regulatory T cells

The paper shows that regulatory T cells suppress protective anti-tumour CD8+ T cell responses by inducing low avidity T cells that are more effective in tumour rejection.

Cities of the future, visualizing climate change to inspire actions

The paper uses climate projections to visualize future city climates, showing how cities will resemble other cities' current climates by 2050 to inspire action on climate change.