Author

J. N. Pugh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:imaging· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1

Frequent Co-Authors

E. Battey· 2 shared G. L. Close· 2 shared J. Ochala· 2 shared M. Kalakoutis· 2 shared R. D. Pollock· 2 shared Y. Levy· 2 shared A. C. Chirgwin· 1 shared A. Hoang· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersPhysiology

E. Battey

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Primary cilia in osteoblasts and osteocytes are required for skeletal development and mechanotransduction

M. Moraes de Lima Perini, J. N. Pugh, E. M. Scott, K. Bhula, A. C. Chirgwin, O. N. Reul, N. F. Berbari, J. Li

This study shows that primary cilia in osteoblasts and osteocytes are essential for skeletal development and mechanotransduction, as demonstrated by reduced bone growth and impaired mechanical loading response in knockout mice.

bioRxiv · Dec 15, 2023 · PreprintCell Biology

Muscle fibre size and myonuclear positioning in trained and aged humans

E. Battey, Y. Levy, R. D. Pollock, J. N. Pugh, G. L. Close, M. Kalakoutis, N. R. Lazarus, S. R. Harridge, J. Ochala, M. J. Stroud

The paper examines how age and physical activity affect muscle fibre size, myonuclear numbers, and myonuclear domain volumes in humans, finding that exercise preserves fibre size and MND relationships while inactivity reduces fibre size and disrupts these relationships.

bioRxiv · Aug 25, 2023Physiology

Myonuclear alterations associated with exercise are independent of age in humans

E. Battey, J. A. Ross, A. Hoang, D. G. S. Wilson, Y. Han, Y. Levy, R. D. Pollock, M. Kalakoutis, J. N. Pugh, G. L. Close, G. M. Ellison-Hughes, N. Lazarus, S. D. R. Harridge, T. Iskratsch, J. Ochala, M. Stroud

This study shows that exercise-induced changes in myonuclear shape and stiffness occur independently of age in humans, potentially preserving muscle function across the lifespan.

bioRxiv · Sep 20, 2022Cell Biology