Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
J. Laitila, R. Seaborne, N. Ranu, J. Kolb, C. Wallgren-Pettersson, N. Witting, J. Vissing, J. J. Vilchez, E. Zanoteli, J. Palmio, S. Huovinen, H. Granzier, J. Ochala
This study tests Mavacamten's ability to rescue metabolic dysregulation in nebulin-deficient muscle, finding it effective in vitro but ineffective in vivo for reversing the proteome changes.
bioRxiv · May 7, 2024Physiology
C. T. A. Lewis, E. G. Melhedegaard, M. M. Ognjanovic, M. S. Olsen, J. Laitila, R. A. E. Seaborne, M. N. Gronset, C. Zhang, H. Iwamoto, A. L. Hessel, M. N. Kuehn, C. Merino, N. Amigo, O. Frobert, S. Giroud, , J. Ochala
This study examines changes in skeletal muscle myosin metabolic states during hibernation in different mammals, finding reduced ATP consumption and potential mechanisms for energy conservation.
bioRxiv · Nov 14, 2023 · PreprintPhysiology
R. Moreno-Justicia, T. Van der Stede, B. Stocks, J. Laitila, R. A. Seaborne, A. Van de Loock, E. Lievens, D. Samodova, L. Marin-Arraiza, O. Dmytriyeva, R. Browaeys, K. Van Vossel, L. Moesgaard, N. Yigit, J. Anckaert, , A. S. Deshmukh
This study identifies sources of skeletal muscle fiber heterogeneity beyond myosin heavy chains using transcriptomic and proteomic data from human muscle fibers.
bioRxiv · Sep 7, 2023Physiology
E. Battey, Y. Levy, R. D. Pollock, J. N. Pugh, G. L. Close, M. Kalakoutis, N. R. Lazarus, S. R. Harridge, J. Ochala, M. J. Stroud
The paper examines how age and physical activity affect muscle fibre size, myonuclear numbers, and myonuclear domain volumes in humans, finding that exercise preserves fibre size and MND relationships while inactivity reduces fibre size and disrupts these relationships.
bioRxiv · Aug 25, 2023Physiology
G. Carrington, A. Hau, S. Kosta, H. Dugdale, F. Muntoni, A. D'Amico, P. Van den Bergh, N. Romero, E. Malfatti, J. J. Vilchez, A. Oldfors, S. Pajusalu, K. Ounap, M. Giralt-Pujol, E. Zanoteli, , J. Ochala
This study investigates how mutations in MYH7 and MYH2 genes affect myosin structure and function, finding that they disrupt coiled-coil structure and increase ATP consumption without affecting contractile function.
bioRxiv · May 15, 2023 · PreprintPhysiology
J. Ochala, C. T. A. Lewis, T. Beck, H. Iwamoto, A. Hessel, K. Campbell, G. Pyle
This study finds that myosin in DCM-affected dogs has increased super-relaxed state and is rescued by EMD-57033.
bioRxiv · Mar 10, 2023Pathology
C. T. A. Lewis, L. Tabrizian, J. Nielsen, J. Laitila, T. N. Beck, P. Aagaard, R. Hokken, S. Laugesen, A. Ingersen, J. L. Andersen, C. Soendenbroe, J. W. Helge, F. Dela, S. Larsen, R. E. Sahl, , J. Ochala
This study shows that endurance training increases the super-relaxed state of myosin in skeletal muscle, reducing ATP turnover and diminishing the effect of the drug Mavacamten.
bioRxiv · Sep 23, 2022 · PreprintPhysiology
E. Battey, J. A. Ross, A. Hoang, D. G. S. Wilson, Y. Han, Y. Levy, R. D. Pollock, M. Kalakoutis, J. N. Pugh, G. L. Close, G. M. Ellison-Hughes, N. Lazarus, S. D. R. Harridge, T. Iskratsch, J. Ochala, M. Stroud
This study shows that exercise-induced changes in myonuclear shape and stiffness occur independently of age in humans, potentially preserving muscle function across the lifespan.
bioRxiv · Sep 20, 2022Cell Biology
J. A. Ross, Y. Levy, M. Ripolone, J. S. Kolb, M. Turmaine, M. Holt, M. Moggio, C. Fiorillo, J. Lindqvist, N. Figeac, P. Zammit, H. Jungbluth, J. Vissing, N. Witting, H. Granzier, , J. Ochala
This study identifies nuclear defects in nemaline myopathy caused by impaired contractility and cytoskeletal organisation in muscle fibres.
bioRxiv · Jan 28, 2019Cell Biology