Author

J. N. Savas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. N. Murphy· 1 shared A. S. Divakaruni· 1 shared A. Shevade· 1 shared B. L. Taylor· 1 shared C. Guillermier· 1 shared C. M. Metallo· 1 shared D. B. van Rossum· 1 shared D. Chung· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperPhysiology

A. N. Murphy

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Author profile →

3 papers

Recent·Most cited

Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan

E. K. Bomba-Warczak, K. M. Velez, L. T. Zhou, C. Guillermier, S. Edassery, M. L. Steinhauser, J. N. Savas, F. Elizabeth Duncan

The paper identifies exceptionally long-lived macromolecules in mammalian ovaries and oocytes that contribute to reproductive health across the lifespan.

bioRxiv · Oct 18, 2023Physiology

A conformational switch driven by phosphorylation regulates Ykt6 activity in macroautophagy

K. McGrath, M. Dergai, S. Agarwal, D. Chung, D. B. van Rossum, A. Shevade, S. Kuchin, S. Zaichick, J. N. Savas, D. Fasshauer, G. Caraveo

This study identifies phosphorylation as a regulator of Ykt6 conformational switch in macroautophagy, revealing its role in Ca2+ signaling and implications for Parkinson's Disease.

bioRxiv · Mar 15, 2020 · PreprintCell Biology

Integrated in vivo quantitative proteomics and nutrient tracing reveals age-related metabolic rewiring of pancreatic β-cell function

M. Wortham, J. R. Benthuysen, M. Wallace, J. N. Savas, F. Mulas, A. S. Divakaruni, F. Liu, V. Albert, B. L. Taylor, Y. Sui, E. Saez, A. N. Murphy, J. R. Yates, C. M. Metallo, M. Sander

This study uses in vivo proteomics and nutrient tracing to show age-related metabolic changes in pancreatic β-cells improve glucose-stimulated insulin secretion.

bioRxiv · Oct 24, 2018Physiology