Author

M. Wortham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2

Frequent Co-Authors

M. Sander· 5 shared A. R. Harrington· 3 shared F. Liu· 3 shared B. Ramms· 2 shared C. M. Metallo· 2 shared D. P. Pollow· 2 shared F. Mulas· 2 shared H. Zhu· 2 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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5 shared papersPhysiology

M. Sander

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Metabolic control of adaptive β-cell proliferation by the protein deacetylase SIRT2

M. Wortham, B. Ramms, C. Zeng, J. R. Benthuysen, S. Sai, D. P. Pollow, F. Liu, M. Schlichting, A. R. Harrington, B. Liu, T. P. Prakash, E. C. Pirie, H. Zhu, S. Baghdasarian, J. Auwerx, , M. Sander

This study identifies SIRT2 as a regulator of β-cell proliferation, showing its role in controlling β-cell expansion during hyperglycemia while preserving feedback mechanisms.

bioRxiv · Feb 24, 2024 · PreprintPhysiology

A vascularized 3D model of the human pancreatic islet for ex vivo study of immune cell-islet interaction

R. H. F. Bender, B. T. O'Donnell, B. Shergill, B. Q. Pham, D. J. Juat, M. S. Hatch, V. S. Shirure, M. Wortham, K.-V. Nguyen-Ngoc, Y. Jun, R. Gaetani, K. L. Christman, L. Teyton, S. C. George, M. Sander, C. C. Hughes

This paper develops a vascularized 3D model of human pancreatic islets to study immune cell interactions and islet destruction in diabetes.

bioRxiv · Dec 21, 2021Cell Biology

Systemic LSD1 inhibition prevents aberrant remodeling of metabolism in obesity

B. Ramms, D. P. Pollow, H. Zhu, C. Nora, A. R. Harrington, I. Omar, P. Gordts, M. Wortham, M. Sander

This study shows that systemic LSD1 inhibition reduces obesity-related metabolic issues like NAFLD and improves insulin sensitivity in mice without affecting lean mice.

bioRxiv · Nov 25, 2021Physiology

Nutrient regulation of the islet epigenome controls adaptive insulin secretion

M. Wortham, F. Liu, J. Y. Fleischman, M. Wallace, F. Mulas, N. K. Vinckier, A. R. Harrington, B. R. Cross, J. Chiou, N. A. Patel, Y. Sui, U. S. Jhala, O. S. Shirihai, M. O. Huising, K. J. Gaulton, , M. Sander

This study shows that nutrient-stimulated histone acetylation regulates the islet epigenome to control adaptive insulin secretion, with Lsd1 playing a key role in this process.

bioRxiv · Aug 21, 2019Physiology

Integrated in vivo quantitative proteomics and nutrient tracing reveals age-related metabolic rewiring of pancreatic β-cell function

M. Wortham, J. R. Benthuysen, M. Wallace, J. N. Savas, F. Mulas, A. S. Divakaruni, F. Liu, V. Albert, B. L. Taylor, Y. Sui, E. Saez, A. N. Murphy, J. R. Yates, C. M. Metallo, M. Sander

This study uses in vivo proteomics and nutrient tracing to show age-related metabolic changes in pancreatic β-cells improve glucose-stimulated insulin secretion.

bioRxiv · Oct 24, 2018Physiology