Author

D. Fasshauer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 4 Biochemistry· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 3 Research Focus:protein folding & dynamics· 3 Research Focus:cell signaling & trafficking· 2 Approach:mechanistic / dynamical model· 2 Organism:mouse· 2 Assay:protein structure· 2 Assay:proteomics· 2

Frequent Co-Authors

F. Varoqueaux· 3 shared D. Khalifeh· 2 shared D. Y. Romanova· 2 shared E. Neveu· 2 shared L. L. Moroz· 2 shared M. A. Nikitin· 2 shared M. Dergai· 2 shared A. B. Kohn· 1 shared

Activity by Year

2019-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersEvolutionary Biology

F. Varoqueaux

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Author profile →

8 papers

Recent·Most cited

A look beyond the QR code of SNARE proteins

D. Yadav, A. Hacisuleyman, M. Dergai, D. Khalifeh, L. A. Abriata, M. Dal Peraro, D. Fasshauer

The paper investigates the structural arrangement of SNARE proteins in QabcR complexes and shows that structural exchange is tolerated but some non-cognate exchanges lead to imbalances.

bioRxiv · Apr 24, 2024Biochemistry

Arachidonic acid does not grease the exocytotic SNARE machinery

D. Fasshauer

The paper shows arachidonic acid does not specifically activate syntaxin 3 but instead acts nonspecifically on SNARE proteins at high concentrations, likely without physiological relevance.

bioRxiv · Feb 6, 2023 · PreprintBiochemistry

Exploring the conformational changes of the Munc18-1/syntaxin 1a complex

I. Stefani, J. Iwaszkiewicz, D. Fasshauer

The paper investigates how Munc18-1 induces conformational changes in syntaxin-1a to facilitate SNARE complex formation, using mutations, structural analysis, and molecular dynamics simulations.

bioRxiv · Nov 29, 2022Biochemistry

Hidden cell diversity in Placozoa: Ultrastructural Insights from Hoilungia hongkongensis

D. Y. Romanova, F. Varoqueaux, J. Daraspe, M. A. Nikitin, M. Eitel, D. Fasshauer, L. L. Moroz

This paper identifies previously unknown cell types in Hoilungia hongkongensis, revealing greater cell diversity in placozoans than previously thought.

bioRxiv · Nov 13, 2020Evolutionary Biology

Choanoflagellates and the ancestry of neurosecretory vesicles

R. Gohde, B. Nauman, D. Laundon, C. Imig, K. L. McDonald, B. H. Cooper, F. Varoqueaux, D. Fasshauer, P. Burkhardt

This study identifies core neurosecretory vesicle proteins in non-bilaterian metazoans and their unicellular relatives, revealing ancestral molecular features and polarized vesicle organization in choanoflagellates.

bioRxiv · May 24, 2020Evolutionary Biology

Nitric oxide (NO) signaling in Trichoplax and related species: Microchemical characterization and the lineage-specific diversification

L. L. Moroz, D. Y. Romanova, M. A. Nikitin, D. Sohn, A. B. Kohn, E. Neveu, F. Varoqueaux, D. Fasshauer

This study characterizes nitric oxide signaling in placozoans, revealing lineage-specific diversification of NOS genes and NO receptors.

bioRxiv · Apr 10, 2020 · PreprintEvolutionary Biology

A conformational switch driven by phosphorylation regulates Ykt6 activity in macroautophagy

K. McGrath, M. Dergai, S. Agarwal, D. Chung, D. B. van Rossum, A. Shevade, S. Kuchin, S. Zaichick, J. N. Savas, D. Fasshauer, G. Caraveo

This study identifies phosphorylation as a regulator of Ykt6 conformational switch in macroautophagy, revealing its role in Ca2+ signaling and implications for Parkinson's Disease.

bioRxiv · Mar 15, 2020 · PreprintCell Biology

Prototypic SNARE proteins are encoded in the genomes of Heimdallarchaeota, potentially bridging the gap between the prokaryotes and eukaryotes

E. Neveu, D. Khalifeh, N. Salamin, D. Fasshauer

The paper identifies SNARE-like proteins in Heimdallarchaeota, suggesting they may be ancestral to eukaryotic SNAREs, and finds evidence of lateral gene transfer in some bacteria.

bioRxiv · Oct 19, 2019Evolutionary Biology