In vivo selection in non-human primates identifies superior AAV capsids for on-target CSF delivery to spinal cord
K. S. Hanlon, M. Cheng, D. De La Cruz, N. Patel, M. C. Santoscoy, Y. Gong, C. Ng, D. M. Nguyen, J. Nammour, S. W. Clark, K. Kozarsky, C. A. Maguire
The paper identifies superior AAV capsids for targeted spinal cord gene therapy in non-human primates through in vivo selection and evaluates their biodistribution and expression.
bioRxiv · Sep 13, 2023 · PreprintBioengineering