Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma
N. R. Campbell, A. Rao, X. Zhang, M. Baron, S. Heilmann, M. Deforet, C. Kenny, L. Ferretti, T.-H. Huang, M. Garg, J. Nsengimana, E. Montal, M. Tagore, M. Hunter, J. Newton-Bishop, , R. White
This study shows that melanoma metastasis is promoted by heterotypic clusters formed between proliferative and invasive cell states, mediated by TFAP2.
bioRxiv · Aug 24, 2020 · PreprintCancer Biology