T.-H. Huang

S100A8/A9 predicts triple-negative breast cancer response to PIM kinase and PD-1/PD-L1 inhibition

Epigenetic reprogramming of melanoma cell state through fatty acid β-oxidation and Toll like receptor 4 signaling

This study shows that fatty acid β-oxidation and TLR4 signaling drive melanoma progression by altering histone acetylation and inflammatory gene expression.

Lipid droplets are a metabolic vulnerability in melanoma

This study identifies lipid droplets as a metabolic vulnerability in melanoma by linking the pigmented cell state to increased fatty acid uptake and oxidative metabolism.

Anatomic position determines oncogenic specificity in melanoma

The paper shows that anatomic position influences oncogenic specificity in melanoma by identifying position-specific gene programs that interact with oncogenes like CRKL.

Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma

This study shows that melanoma metastasis is promoted by heterotypic clusters formed between proliferative and invasive cell states, mediated by TFAP2.

ZmMTOPVIB is essential for double-strand break formation and bipolar spindle assembly in maize meiosis

This study shows ZmMTOPVIB is essential for DSB formation and bipolar spindle assembly in maize meiosis, with conserved functions in monocots.