M. Baron

Deep Brain Stimulation of Nucleus Basalis of Meynert improves learning in rat model of dementia.

This study evaluates the effects of different deep brain stimulation patterns and durations on learning in a rat dementia model, finding that burst stimulation improves cognitive performance.

Drug-induced adaptation along a resistance continuum in cancer cells

This study shows that gradual dose exposure and prolonged treatment drive ovarian cancer cell resistance to targeted therapy through a continuous adaptation process involving transcriptional, epigenetic, and genetic changes.

Recurrence of cancer cell states across diverse tumors and their interactions with the microenvironment

The paper identifies recurrent cancer cell states across 15 tumor types and examines their interactions with the tumor microenvironment using single-cell RNA-Seq and spatial transcriptomics.

Electrical activity between skin cells regulates melanoma initiation

The paper shows GABAergic signaling between keratinocytes and melanoma cells promotes melanoma initiation via BRAFV600E, with electrical activity regulating oncogenic competence.

Spatial epitope barcoding reveals subclonaltumor patch behaviors

The paper develops a method to track subclonal tumor patch behaviors using spatial epitope barcoding and imaging, revealing emergent properties in cancer cell states.

Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma

This study shows that melanoma metastasis is promoted by heterotypic clusters formed between proliferative and invasive cell states, mediated by TFAP2.

Inhibition of Wnt signalling by Notch via two distinct mechanisms

The paper identifies two distinct mechanisms by which Notch inhibits Wnt signaling by limiting β-catenin transcriptional activity in vertebrate cells.

A population of stress-like cancer cells in melanoma promotes tumorigenesis and confers drug resistance

The paper identifies a stress-like cancer cell state in melanoma that promotes tumorigenesis and drug resistance, validated across zebrafish and human models.

Integrating single-cell RNA-Seq with spatial transcriptomics in pancreatic ductal adenocarcinoma using multimodal intersection analysis

This study integrates single-cell RNA-Seq and spatial transcriptomics data from pancreatic cancer tissue to map cell type spatial distributions and infer tissue architecture.

Widespread transcriptional scanning in the testis modulates gene evolution rates

The paper maps gene expression in human spermatogenesis and finds that expressed genes have fewer germline mutations, suggesting transcriptional scanning reduces DNA damage and influences gene evolution rates.