N. R. Campbell

Epigenetic reprogramming of melanoma cell state through fatty acid β-oxidation and Toll like receptor 4 signaling

This study shows that fatty acid β-oxidation and TLR4 signaling drive melanoma progression by altering histone acetylation and inflammatory gene expression.

Anatomic position determines oncogenic specificity in melanoma

The paper shows that anatomic position influences oncogenic specificity in melanoma by identifying position-specific gene programs that interact with oncogenes like CRKL.

Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma

This study shows that melanoma metastasis is promoted by heterotypic clusters formed between proliferative and invasive cell states, mediated by TFAP2.

Developmental chromatin programs determine oncogenic competence in melanoma

The paper shows that BRAFV600E transforming ability depends on the cell of origin's transcriptional program, with neural crest and melanoblasts being more susceptible due to higher chromatin modifying enzyme expression and ATAD2-SOX10 complex formation.

A population of stress-like cancer cells in melanoma promotes tumorigenesis and confers drug resistance

The paper identifies a stress-like cancer cell state in melanoma that promotes tumorigenesis and drug resistance, validated across zebrafish and human models.

Cancer modeling by Transgene Electroporation in Adult Zebrafish (TEAZ)

The paper introduces TEAZ, a method to rapidly model cancer in zebrafish by delivering gene constructs to specific cells, enabling faster tumor development and tracking.