A novel role for cystathionine gamma lyase in the control of p53: impact on endothelial senescence and metabolic reprograming
J. Hu, M. S. Leisegang, M. Looso, G. Dumbovic, J. Wittig, M.-K. Drekolia, S. Guenther, D. John, M. Siragusa, S. Zukunft, J. Oo, I. Wittig, S. Hille, A. Weigert, S. Knapp, , S. I. Bibli
This paper identifies CSE-p53 interaction as a regulator of endothelial cell senescence and metabolic reprogramming in aging, showing that restoring this interaction can prevent senescence and promote vascular repair.
bioRxiv · Sep 5, 2022 · PreprintCell Biology