An Acyclic Phosphonate Prodrug of HPMPC is Effective Against VZV in Skin Organ Culture and Mice
M. G. Lloyd, D. Liu, J. Lyu, J. Fan, J. Overhulse, B. A. Kashemirov, M. N. Prichard, C. E. McKenna, J. F. Moffat
This study develops and evaluates USC-373, a phosphonate prodrug of HPMPC, showing efficacy against VZV in cell cultures and mouse models with improved potency and bioavailability.
bioRxiv · Jan 30, 2022Microbiology