Author

C. E. McKenna

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:C. elegans· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

B. A. Kashemirov· 2 shared C. Garnaud· 1 shared C. Petosa· 1 shared D. Liu· 1 shared G. Bourgine· 1 shared G. Rabut· 1 shared J. F. Moffat· 1 shared J. Fan· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

B. A. Kashemirov

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2 papers

Recent·Most cited

Targeting fungal BET bromodomains as a pan-Candida antifungal strategy

K. Wei, J. M. Overhulse, M. Arlotto, Y. Zhou, N. J. Dupper, B. A. Kashemirov, C. Garnaud, G. Bourgine, M. Cornet, G. Rabut, C. E. McKenna, C. Petosa, J. Govin

This study identifies a phenyltriazine compound that selectively targets both Bdf1 bromodomains in Candida species, showing antifungal activity against multiple Candida strains including resistant isolates.

bioRxiv · Feb 3, 2023 · PreprintBiochemistry

An Acyclic Phosphonate Prodrug of HPMPC is Effective Against VZV in Skin Organ Culture and Mice

M. G. Lloyd, D. Liu, J. Lyu, J. Fan, J. Overhulse, B. A. Kashemirov, M. N. Prichard, C. E. McKenna, J. F. Moffat

This study develops and evaluates USC-373, a phosphonate prodrug of HPMPC, showing efficacy against VZV in cell cultures and mouse models with improved potency and bioavailability.

bioRxiv · Jan 30, 2022Microbiology