J. P. Davies

Cell-Free Optimized Production of Protoporphyrin IX

This study develops a cell-free metabolic engineering platform to produce protoporphyrin IX, achieving 0.109 mg/mL yields through optimized buffer conditions and co-culturing techniques.

SARS-CoV-2 Nonstructural Proteins 3 and 4 tune the Unfolded Protein Response

This study investigates how SARS-CoV-2 nonstructural proteins 3 and 4 modulate the Unfolded Protein Response (UPR) through proteomic analysis, revealing their distinct roles in activating specific UPR branches.

Comparative host interactomes of the SARS-CoV-2 nonstructural protein 3 and human coronavirus homologs

This study compares the host interactomes of SARS-CoV-2 nsp3 and its coronavirus homologs to identify differences in host interactions that may contribute to pathogenicity.

Comparative multiplexed interactomics of SARS-CoV-2 and homologous coronavirus non-structural proteins identifies unique and shared host-cell dependencies

This study compares the interactomes of SARS-CoV-1, SARS-CoV-2, and hCoV-OC43 non-structural proteins to identify unique and shared host-cell dependencies, revealing potential therapeutic targets.

Dengue and Zika virus infection are impaired by small molecule ER proteostasis regulator 147 in an ATF6-independent manner

This study shows that compound 147 reduces Dengue and Zika virus infection by targeting ER proteostasis without relying on ATF6 activation.