M. S. Lee

T cell cholesterol transport is a metabolic checkpoint that links intestinal immune responses to dietary lipid absorption

This study identifies Aster-A as a cholesterol transporter in T cells that regulates immune signaling and metabolic responses by controlling membrane cholesterol levels.

Discovery of Highly Active Kynureninases for Cancer Immunotherapy through Protein Language Model

The paper identifies and validates four kynureninases using homology searches and protein language models, with the most active one showing significant tumor reduction in mouse models.

Cell-Free Optimized Production of Protoporphyrin IX

This study develops a cell-free metabolic engineering platform to produce protoporphyrin IX, achieving 0.109 mg/mL yields through optimized buffer conditions and co-culturing techniques.

Functional immune state classification of unlabeled live human monocytes using holotomography and machine learning

This study uses holotomography and machine learning to classify functional immune states of human monocytes, achieving high accuracy in identifying hyper-inflammatory and immune-suppressed states.

The CD4 transmembrane GGXXG and juxtamembrane (C/F)CV+C motifs mediate pMHCII-specific signaling independently of CD4-Lck interactions

This study shows that CD4's GGXXG and (C/F)CV+C motifs are critical for pMHCII-specific signal amplification without requiring CD4-LCK interactions.

TET1 controls Cxcl1 induction by DNA demethylation and promotes neutrophil recruitment during acute lung injury

This study shows TET1 facilitates DNA demethylation of the Cxcl1 promoter, enabling its induction and neutrophil recruitment during acute lung injury.

Enhancing and inhibitory motifs have coevolved to regulate CD4 activity

The paper shows that enhancing and inhibitory motifs in CD4 coevolved to regulate pMHCII responses by fine-tuning signal relay across the cell membrane.

Analysis of the blood microbiome in a porcine model of fecal-induced peritonitis

This study analyzes the blood microbiome in a porcine model of fecal-induced peritonitis, finding stable bacterial populations and taxonomic differences between fecal and blood microbiomes.

Fab-dimerized glycan-reactive antibodies neutralize HIV and are prevalent in humans and rhesus macaques

The paper identifies Fab-dimerized glycan-reactive antibodies in HIV-infected macaques and HIV-naïve humans that neutralize HIV-1 and can be elicited by vaccination.

Peptide recognition and dephosphorylation by the vaccinia VH1 phosphatase

This study identifies key amino acid residues in the vaccinia VH1 phosphatase that mediate substrate recognition and dephosphorylation, offering new targets for inhibitor development.

A biomimetic five-module chimeric antigen receptor (5MCAR) designed to target and eliminate antigen-specific T cells

This paper designs a biomimetic 5MCAR to target and eliminate antigen-specific T cells, showing it can mitigate type I diabetes in NOD mice.