Author

J. P. Garnett

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

E. Schruf· 2 shared H. Q. Le· 2 shared K. Quast· 2 shared M. J. Thomas· 2 shared V. Schroeder· 2 shared A. Bourdin· 1 shared A. C. M. Khan· 1 shared A. I. Gardner· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCell Biology

E. Schruf

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2

C. F. Hatton, R. A. Botting, M. E. Duenas, I. J. Haq, B. Verdon, B. J. Thompson, J. Stremenova Spegarova, F. Gothe, E. A. Stephenson, A. I. Gardner, S. Murphy, J. Scott, J. P. Garnett, S. Carrie, J. Powell, , C. J. A. Duncan

This study shows that delayed type I and III interferon responses in nasal epithelial cells allow SARS-CoV-2 replication, but pre-infection IFN treatment restricts virus and preserves barrier integrity.

bioRxiv · Feb 17, 2021Immunology

Differentiation of human induced pluripotent stem cells into functional airway epithelium

E. Ahmed, M. Fieldes, C. Bourguignon, J. Mianne, A. Petit, C. Vernisse, M. Jory, C. Cazevieille, H. Boukhaddaoui, J. P. Garnett, G. Massiera, I. Vachier, S. Assou, A. Bourdin, J. De Vos

This paper describes a method to differentiate human induced pluripotent stem cells into functional airway epithelium, achieving high cell purity and successful differentiation into multiple cell types.

bioRxiv · Nov 29, 2020 · PreprintBioengineering

A polycomb-independent role of EZH2 in TGFβ1-damaged epithelium triggers a fibrotic cascade with mesenchymal cells

H. Q. Le, M. A. Hill, I. Kollak, W. Skronska-Wasek, V. Schroeder, J. Wirth, E. Schruf, K. Quast, F. E. Herrmann, M. J. Thomas, J. P. Garnett

The paper shows that EZH2, independent of Polycomb, drives fibrosis in TGFβ1-damaged epithelium by forming a new transcriptional complex with POL2 and nuclear actin.

bioRxiv · Jul 29, 2020Cell Biology

Recapitulating idiopathic pulmonary fibrosis related alveolar epithelial dysfunction in an iPSC-derived air-liquid interface model

E. Schruf, V. Schroeder, H. Q. Le, T. Schoenberger, D. Raedel, E. L. Stewart, K. Fundel-Clemens, T. Bluhmki, S. Weigle, M. Schuler, M. J. Thomas, R. Heilker, M. J. Webster, M. Dass, M. Frick, , J. P. Garnett

This study develops an iPSC-derived air-liquid interface model to mimic IPF-related bronchiolization and shows IPF-RC stimulation alters ATII differentiation and transcriptome profiles.

bioRxiv · Nov 4, 2019Cell Biology