Author

C. F. Hatton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:scRNA-seq· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

S. Hambleton· 3 shared C. J. A. Duncan· 2 shared C. Ward· 2 shared F. Gothe· 2 shared I. J. Haq· 2 shared M. Brodlie· 2 shared M. Haniffa· 2 shared R. Hussain· 2 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

S. Hambleton

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Type I interferons govern Zika virus resistance of human macrophages and microglia

A. T. Hanrath, C. F. Hatton, F. Gothe, C. Browne, J. Vowles, P. Leary, S. J. Cockell, S. A. Cowley, W. S. James, S. Hambleton, C. J. A. Duncan

This study shows that type I interferons restrict Zika virus replication in macrophages and microglia, and their suppression increases viral replication and cell damage.

bioRxiv · Mar 9, 2022 · PreprintCell Biology

Conjunctival epithelial cells resist productive SARS-CoV-2 infection

M. Lako, R. M. Jackson, C. F. Hatton, J. S. Spegarova, M. Georgiou, J. Collin, E. Stephenson, B. Vernon, I. J. Haq, R. Hussain, J. M. Coxhead, H. S. Mudhar, B. Wagner, M. Hasoon, T. Davie, , C. J. Duncan

The paper investigates whether conjunctival epithelial cells can be infected by SARS-CoV-2 and finds that while genome expression occurs, productive infection does not.

bioRxiv · Dec 20, 2021Cell Biology

Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2

C. F. Hatton, R. A. Botting, M. E. Duenas, I. J. Haq, B. Verdon, B. J. Thompson, J. Stremenova Spegarova, F. Gothe, E. A. Stephenson, A. I. Gardner, S. Murphy, J. Scott, J. P. Garnett, S. Carrie, J. Powell, , C. J. A. Duncan

This study shows that delayed type I and III interferon responses in nasal epithelial cells allow SARS-CoV-2 replication, but pre-infection IFN treatment restricts virus and preserves barrier integrity.

bioRxiv · Feb 17, 2021Immunology