Author

M. J. Thomas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Immunology· 3 Biochemistry· 2 Ecology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 4 Assay:bulk RNA-seq· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 2

Frequent Co-Authors

B. Stierstorfer· 2 shared E. Schruf· 2 shared H. Q. Le· 2 shared J. P. Garnett· 2 shared K. Quast· 2 shared T. Schoenberger· 2 shared V. Schroeder· 2 shared A. G. Lynch· 1 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCell Biology

B. Stierstorfer

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Author profile →

10 papers

Recent·Most cited

Scavenger receptor class B type I is required for efficient glucose uptake and metabolic homeostasis in adipocytes

D. A. Knaack, J. Chang, M. J. Thomas, M. Sorci-Thomas, Y. Chen, D. Sahoo

This study shows that SR-BI is necessary for efficient glucose uptake and metabolic homeostasis in adipocytes, as its absence leads to reduced glucose uptake and altered lipid metabolism.

bioRxiv · Aug 21, 2023 · PreprintBiochemistry

Three dimensional fibrotic extracellular matrix directs microenvironment fiber remodeling by fibroblasts

M. Nizamoglu, F. Alleblas, T. Koster, T. Borghuis, J. M. Vonk, M. J. Thomas, E. S. White, C. Kirstin Watson, W. Timens, K. C. El Kasmi, B. N. Melgert, I. H. Heijink, J. K. Burgess

This study shows that 3D fibrotic ECM hydrogels alter fibroblast fiber organization and mechanical properties, promoting pro-fibrotic responses.

bioRxiv · Aug 9, 2023Pathology

Intraspecific variation in migration timing of green sturgeon in the Sacramento River system

S. F. Colborne, L. W. Sheppard, D. R. O'Donnell, D. C. Reuman, J. A. Walter, G. P. Singer, J. T. Kelly, M. J. Thomas, A. L. Rypel

The paper analyzes migration timing of green sturgeon in the Sacramento River system using acoustic telemetry data, finding bimodal out-migration patterns influenced by river discharge.

bioRxiv · Dec 3, 2021Ecology

Kinetic characterization and thermostability of C. elegans cytoplasmic and mitochondrial malate dehydrogenases

M. J. Thomas, E. R. Cassidy, D. S. Robinson, K. M. Walstrom

This study compares the kinetic and thermostability properties of cytoplasmic and mitochondrial malate dehydrogenases in C. elegans, finding MDH-1 more thermostable due to structural differences.

bioRxiv · Jul 8, 2021Biochemistry

Characterization of a flexible AAV-DTR/DT mouse model of acute epithelial lung injury

E. Griesser, T. Schoenberger, B. Stierstorfer, H. Wyatt, W. Rist, T. Lamla, M. J. Thomas, D. Lamb, K. Geillinger-Kaestle

The paper develops an AAV-DTR/DT mouse model of acute epithelial lung injury and shows it mimics features of IPF and ARDS.

bioRxiv · Jun 18, 2021Cell Biology

Dynamics of repair and regeneration of adult zebrafish respiratory gill tissue after cryoinjury.

M.-C. Ramel, F. Progatzky, A. Rydlova, M. Wane, J. Schymeinsky, C. Williams, B. Jung, J. Lamb, M. J. Thomas, L. Bugeon, M. J. Dallman

This study investigates zebrafish gill regeneration after cryoinjury, identifying FIBIN as a gene involved in resolving tissue damage without fibrosis.

bioRxiv · May 27, 2021 · PreprintImmunology

A polycomb-independent role of EZH2 in TGFβ1-damaged epithelium triggers a fibrotic cascade with mesenchymal cells

H. Q. Le, M. A. Hill, I. Kollak, W. Skronska-Wasek, V. Schroeder, J. Wirth, E. Schruf, K. Quast, F. E. Herrmann, M. J. Thomas, J. P. Garnett

The paper shows that EZH2, independent of Polycomb, drives fibrosis in TGFβ1-damaged epithelium by forming a new transcriptional complex with POL2 and nuclear actin.

bioRxiv · Jul 29, 2020Cell Biology

Whole-genome sequencing of a sporadic primary immunodeficiency cohort

J. E. D. Thaventhiran, H. Lango Allen, O. S. Burren, W. Rae, D. Greene, E. Staples, Z. Zhang, J. H. R. Farmery, I. Simeoni, J. Maimaris, C. Penkett, J. Stephens, S. V. V. Deevi, A. Sanchis-Juan, N. S. Gleadall, , Kuma

This study uses whole-genome sequencing of a PID cohort to identify genetic mutations and associations, revealing both monogenic and common variant contributions to immune dysfunction.

bioRxiv · May 7, 2020Immunology

Recapitulating idiopathic pulmonary fibrosis related alveolar epithelial dysfunction in an iPSC-derived air-liquid interface model

E. Schruf, V. Schroeder, H. Q. Le, T. Schoenberger, D. Raedel, E. L. Stewart, K. Fundel-Clemens, T. Bluhmki, S. Weigle, M. Schuler, M. J. Thomas, R. Heilker, M. J. Webster, M. Dass, M. Frick, , J. P. Garnett

This study develops an iPSC-derived air-liquid interface model to mimic IPF-related bronchiolization and shows IPF-RC stimulation alters ATII differentiation and transcriptome profiles.

bioRxiv · Nov 4, 2019Cell Biology

Systematic profiling of full-length immunoglobulin and T-cell receptor repertoire diversity in rhesus macaque through long read transcriptome sequencing

H. Brochu, E. Tseng, E. Smith, M. J. Thomas, A. Jones, K. Diveley, L. Law, S. G. Hansen, L. Picker, M. Gale, X. Peng

This study uses long-read sequencing to profile full-length Ig and TCR repertoires in rhesus macaques, revealing significant diversity missed by traditional methods.

bioRxiv · Oct 15, 2019Immunology