Andrew G. Edwards

The paper uses computational modeling to identify key parameters controlling glucose-induced excitability diversity in human pancreatic β-cells.

This study evaluates two β-cell network models, introduces heterogeneity based on single-cell gene expression, and incorporates paracrine signaling to improve physiological realism.

This study investigates how intrinsic metabolic and electrophysiologic properties and ionic coupling contribute to the beta hub cell phenotype in pancreatic islets.

This paper investigates how empagliflozin affects late sodium currents in specific LQT3 mutations, finding it selectively inhibits these currents in some mutations but not others.

The paper develops statistical translators to map cardiac myocyte electrophysiological responses across species, validated with experimental data and simulations.

The paper develops a biochemically detailed computational model of cortical post-synaptic plasticity that integrates multiple signalling pathways and reproduces observed plasticity phenomena.