Non-canonical autophagy in dendritic cells restricts cross-presentation and anti-tumor immunity
P. Sil, G. W. Muse, S.-W. Wong, J. P. Kolb, L. M. DeGraff, C. J. Tucker, E. Scappini, A. G. Snyder, S. Grimm, A. Oberst, J. Martinez
This study shows that Rubicon deficiency in dendritic cells enhances cross-presentation and anti-tumor immunity by increasing phagosome-to-cytosol escape and antigen degradation.
bioRxiv · Oct 2, 2019 · PreprintImmunology