Molecular Basis for the Evolved Instability of a Human G-Protein Coupled Receptor
L. M. Chamness, N. B. Zelt, C. P. Kuntz, B. J. Bender, W. D. Penn, J. J. Ziarek, J. P. Meiler, J. P. Schlebach
The paper identifies a C-terminal truncation and increased TM domain polarity in GnRHR as evolutionary adaptations that reduce receptor stability and activity.
bioRxiv · Dec 20, 2019Biochemistry