Author

B. J. Bender

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Basbaum· 1 shared A. Geanes· 1 shared B. Allison· 1 shared B. K. Shoichet· 1 shared B. L. Roth· 1 shared C. P. Kuntz· 1 shared E. Okwei· 1 shared H. J. Kang· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperPharmacology & Toxicology

A. Basbaum

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structure-Based Discovery of a NPFF1R Antagonist with Analgesic Activity

B. J. Bender, J. E. Pickett, J. Braz, H. J. Kang, S. Gahbauer, K. Bhardwaj, S. Rodriguez-Rosado, Y. Liu, M. Jain, A. Basbaum, B. L. Roth, B. K. Shoichet

This paper identifies a selective NPFF1R antagonist with analgesic properties, showing enhanced pain relief when combined with morphine and reduced side effects.

bioRxiv · Oct 25, 2023 · PreprintPharmacology & Toxicology

Rosetta 's Predictive Ability for Low-Affinity Ligand Binding in Fragment-Based Drug Discovery

E. Okwei, S. Smith, B. J. Bender, B. Allison, S. Ganguly, A. Geanes, X. Zhang, K. Ledwitch, J. Meiler

This study evaluates RosettaLigand's ability to predict low-affinity ligand binding in fragment-based drug discovery using NMR data and finds it ranks binders with an AUC of 0.74.

bioRxiv · Oct 18, 2022Biochemistry

Molecular Basis for the Evolved Instability of a Human G-Protein Coupled Receptor

L. M. Chamness, N. B. Zelt, C. P. Kuntz, B. J. Bender, W. D. Penn, J. J. Ziarek, J. P. Meiler, J. P. Schlebach

The paper identifies a C-terminal truncation and increased TM domain polarity in GnRHR as evolutionary adaptations that reduce receptor stability and activity.

bioRxiv · Dec 20, 2019Biochemistry