Author

W. D. Penn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 7 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 8 Organism:human· 5 Research Focus:protein folding & dynamics· 5 Approach:deep learning· 4 Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 4 Approach:statistical model· 4 Research Focus:cell type annotation· 2

Frequent Co-Authors

J. P. Schlebach· 8 shared C. P. Kuntz· 6 shared A. G. McKee· 5 shared L. M. Chamness· 5 shared F. J. Roushar· 4 shared J. Meiler· 3 shared B. Jastrzebska· 2 shared E. F. McDonald· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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8 shared papersBiochemistry

J. P. Schlebach

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8 papers

Recent·Most cited

Ribosomal Frameshifting Selectively Modulates the Assembly, Function, and Pharmacological Rescue of a Misfolded CFTR Variant

P. Carmody, F. J. Roushar, A. Tedman, W. Wang, M. Herwig, M. Kim, E. F. McDonald, K. Noguera, J. Wong-Roushar, J.-L. Poirier, N. Zelt, B. Pockrass, A. G. McKee, C. P. Kuntz, S. V. Raju, , J. P. Schlebach

This paper identifies an RNA structure in the CFTR transcript that promotes ribosomal frameshifting and premature termination, enhancing the function and pharmacological rescue of the misfolded {Delta}F508 CFTR variant.

Proceedings of the National Academy of Sciences · Oct 10, 2024Peer-reviewedBiochemistry

Divergent Folding-Mediated Epistasis Among Unstable Membrane Protein Variants

L. M. Chamness, C. P. Kuntz, A. G. McKee, W. D. Penn, C. M. Hemmerich, D. B. Rusch, H. Woods, Dyotima, J. Meiler, J. P. Schlebach

The paper examines how mutations in unstable membrane proteins like GnRHR form distinct epistatic interactions depending on their destabilizing mechanisms and severity.

bioRxiv · Aug 25, 2023Biochemistry

Elucidation of Global Trends in the Effects of VX-661 and VX-445 on the Expression of Clinical CFTR Variants

A. G. McKee, E. F. McDonald, W. D. Penn, C. P. Kuntz, K. Noguera, L. M. Chamness, F. J. Roushar, J. Meiler, K. E. Oliver, L. Plate, J. P. Schlebach

This study compares the effects of VX-661 and VX-445 on 129 CFTR variants using deep mutational scanning, finding distinct patterns of expression rescue based on variant destabilization and binding pocket locations.

bioRxiv · Oct 14, 2022 · PreprintBiochemistry

Chromenone derivatives as novel pharmacological chaperones for retinitis pigmentosa-linked rod opsin mutants

J. T. Ortega, A. G. McKee, F. J. Roushar, W. D. Penn, J. P. Schlebach, B. Jastrzebska

This study identifies a chromenone derivative that stabilizes rod opsin mutants, rescues membrane trafficking in vitro, and protects photoreceptors in vivo in RP models.

bioRxiv · Apr 5, 2022Pharmacology & Toxicology

Molecular Basis for Variations in the Sensitivity of Pathogenic Rhodopsin Variants to 9-cis-Retinal

F. J. Roushar, A. G. McKee, C. P. Kuntz, J. T. Ortega, W. D. Penn, H. Woods, L. M. Chamness, V. Most, J. Meiler, B. Jastrzebska, J. P. Schlebach

This study uses deep mutational scanning to analyze how 123 pathogenic rhodopsin variants respond to 9-cis-retinal, identifying variants with diminished membrane expression and varying sensitivity to retinal.

bioRxiv · Mar 1, 2022Biochemistry

Coordination of -1 Programmed Ribosomal Frameshifting by Transcript and Nascent Chain Features Revealed by Deep Mutational Scanning

P. J. Carmody, M. H. Zimmer, C. P. Kuntz, H. R. Harrington, K. E. Duckworth, W. D. Penn, S. Mukhopahyay, T. F. Miller, J. P. Schlebach

The paper uses deep mutational scanning to analyze how mutations affect -1PRF in alphavirus polyproteins, revealing coordination between transcript and nascent chain features.

bioRxiv · Mar 11, 2021Biochemistry

Cotranslational Folding Stimulates Programmed Ribosomal Frameshifting in the Alphavirus Structural Polyprotein

H. R. Harrington, M. H. Zimmer, L. M. Chamness, V. Nash, W. D. Penn, T. F. Miller, S. Mukhopadhyay, J. P. Schlebach

This study shows that cotranslational folding of a nascent polypeptide chain can stimulate programmed ribosomal frameshifting in the Sindbis virus structural polyprotein.

bioRxiv · Jan 16, 2020Biochemistry

Molecular Basis for the Evolved Instability of a Human G-Protein Coupled Receptor

L. M. Chamness, N. B. Zelt, C. P. Kuntz, B. J. Bender, W. D. Penn, J. J. Ziarek, J. P. Meiler, J. P. Schlebach

The paper identifies a C-terminal truncation and increased TM domain polarity in GnRHR as evolutionary adaptations that reduce receptor stability and activity.

bioRxiv · Dec 20, 2019Biochemistry