Disparate Bone Anabolic Cues Activate Bone Formation by Regulating the Rapid Lysosomal Degradation of Sclerostin Protein
N. R. Gould, K. M. Williams, H. C. Joca, O. M. Torre, J. S. Lyons, J. M. Leser, M. P. Srikanth, M. Hughes, R. J. Khairallah, R. A. Feldman, C. W. Ward, J. P. Stains
This study shows mechanical and hormonal cues promote bone formation by rapidly degrading sclerostin via lysosomes, challenging the previous view that sclerostin regulation is solely transcriptional.
bioRxiv · Oct 26, 2020Cell Biology