M. Hughes

Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function

CAFs with a myofibroblastic-like phenotype transfer proteins to ECs, including plasma membrane receptors, through matrix-bound EVs.

Single-cell landscapes of primary glioblastomas and matched organoids and cell lines reveal variable retention of inter- and intra-tumor heterogeneity

The paper analyzes genetic and transcriptional profiles of glioblastomas, organoids, and cell lines to show variable retention of tumor heterogeneity in organoids and uniformity in cell lines.

Disparate Bone Anabolic Cues Activate Bone Formation by Regulating the Rapid Lysosomal Degradation of Sclerostin Protein

This study shows mechanical and hormonal cues promote bone formation by rapidly degrading sclerostin via lysosomes, challenging the previous view that sclerostin regulation is solely transcriptional.

The genomic landscape of intrinsic and acquired resistance to cyclin-dependent kinase 4/6 inhibitors in patients with hormone receptor positive metastatic breast cancer

The paper identifies eight resistance mechanisms to CDK4/6 inhibitors in HR+ breast cancer, present in 80% of resistant tumors, with potential therapeutic strategies.

Observations on the interactions of mammals and birds with badger (Meles meles) dung pits at a site used by a single social group in an urban area

The paper observes mammalian and avian interactions with badger dung pits using infrared cameras, finding 28% of behaviors involve material harvesting.

Host density dependence and environmental factors affecting laurel wilt invasion

The paper investigates how host density, size, and environmental factors influence the spread of laurel wilt disease in Persea species across different sites.

NGS-based assay for frequent newborn inherited diseases: from development to implementation

The paper develops and validates an NGS-based assay for diagnosing common newborn inherited diseases and reports its successful clinical implementation.