Author

R. J. Khairallah

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

A. Douillette· 1 shared A. Nguyen· 1 shared B. G. Allen· 1 shared B. Hussein· 1 shared B. Lauzier· 1 shared C. Fiset· 1 shared C. W. Ward· 1 shared D. Dingar· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperPhysiology

A. Douillette

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2 papers

Recent·Most cited

MK2-deficient mice are bradycardic and display delayed hypertrophic remodelling in response to a chronic increase in afterload

M. Ruiz, M. Khairallah, D. Dingar, G. Vaniotis, R. J. Khairallah, B. Lauzier, S. Thibault, J. Trepanier, Y. Shi, A. Douillette, B. Hussein, S. A. Nawaito, P. Sahadevan, A. Nguyen, M.-A. Gillis, , B. G. Allen

This study examines the cardiac phenotype of MK2-deficient mice, finding altered autonomic regulation, increased metabolic gene expression, reduced mitochondrial Ca2+-sensitivity, and delayed hypertrophic remodeling in response to pressure overload.

Journal of the American Heart Association · Feb 16, 2021Peer-reviewedPhysiology

Disparate Bone Anabolic Cues Activate Bone Formation by Regulating the Rapid Lysosomal Degradation of Sclerostin Protein

N. R. Gould, K. M. Williams, H. C. Joca, O. M. Torre, J. S. Lyons, J. M. Leser, M. P. Srikanth, M. Hughes, R. J. Khairallah, R. A. Feldman, C. W. Ward, J. P. Stains

This study shows mechanical and hormonal cues promote bone formation by rapidly degrading sclerostin via lysosomes, challenging the previous view that sclerostin regulation is solely transcriptional.

bioRxiv · Oct 26, 2020Cell Biology