Pharmacological inhibition of the amino-acid transporter LAT1 demonstrates in vitro anti-neoplastic activity towards medulloblastoma
Y. Cormerais, M. Pagnuzzi-Boncompagni, S. Schrötter, S. Giuliano, E. Tambutte, H. Endou, M. F. Wempe, G. Pages, J. Pouyssegur, V. Picco
This study shows that JPH203, a LAT1 inhibitor, effectively reduces medulloblastoma cell proliferation and survival without harming normal cells.
bioRxiv · Jan 8, 2019Cancer Biology