Author

M. F. Wempe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Organism:mouse· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

H. Endou· 2 shared A. Clarke· 1 shared A. Filer· 1 shared A. Green· 1 shared A. M. Thomas· 1 shared A. Mongin· 1 shared A. Pierce· 1 shared B. Brunt· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersImmunology

H. Endou

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

MRI-Guided Focused Ultrasound Blood-Brain Barrier Opening Increases Drug Delivery and Efficacy in a Diffuse Midline Glioma Mouse Model

P. J. Martinez, G. Nault, J. Steiner, M. F. Wempe, A. Pierce, B. Brunt, M. Slade, A. Mongin, J. J. Song, K.-H. Song, N. Ellens, N. Serkova, A. Green, M. A. Borden

MRI-guided focused ultrasound with microbubbles increases panobinostat delivery and efficacy in a diffuse midline glioma mouse model, reducing tumor volume and improving survival.

bioRxiv · Apr 5, 2023Bioengineering

LAT1 enables T cell activation under inflammatory conditions: a new therapeutic target for rheumatoid arthritis

J. Ogbechi, H. L. Wright, S. Balint, L. Topping, K. Zec, I.-S. Huang, E. Pantazi, M. Swart, D. Windell, E. Marin, M. F. Wempe, H. Endou, A. M. Thomas, A. Filer, T. W. Stone, , R. Williams

This study shows LAT1 is critical for T cell activation in rheumatoid arthritis and identifies it as a therapeutic target, with a LAT1 inhibitor effective in mouse models.

bioRxiv · Dec 20, 2022 · PreprintImmunology

Pharmacological inhibition of the amino-acid transporter LAT1 demonstrates in vitro anti-neoplastic activity towards medulloblastoma

Y. Cormerais, M. Pagnuzzi-Boncompagni, S. Schrötter, S. Giuliano, E. Tambutte, H. Endou, M. F. Wempe, G. Pages, J. Pouyssegur, V. Picco

This study shows that JPH203, a LAT1 inhibitor, effectively reduces medulloblastoma cell proliferation and survival without harming normal cells.

bioRxiv · Jan 8, 2019Cancer Biology