Facilitation of TRKB activation by the angiotensin II receptor type-2 (AT2R) agonist C21
L. Laukkanen, C. R. A. F. Dinz, S. Foulquier, J. Prickaerts, E. Castren, P. C. Casarotto
This study shows that C21, an AT2R agonist, increases TRKB surface levels and enhances BDNF's effect on pTRKB in neurons, reducing freezing time in mice in a BDNF-dependent manner without affecting anxiety.
bioRxiv · Jul 20, 2021Pharmacology & Toxicology