Author

P. C. Casarotto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 3 Animal Behavior & Cognition· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Organism:rat· 2 Assay:behavioral assay· 1

Frequent Co-Authors

E. Castren· 4 shared C. Biojone· 2 shared L. Laukkanen· 2 shared S. R. L. Joca· 2 shared A. J. Sales· 1 shared C. Brunello· 1 shared C. R. A. F. Dinz· 1 shared F. Q. Cunha· 1 shared

Activity by Year

2016-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersPharmacology & Toxicology

E. Castren

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4 papers

Recent·Most cited

Facilitation of TRKB activation by the angiotensin II receptor type-2 (AT2R) agonist C21

L. Laukkanen, C. R. A. F. Dinz, S. Foulquier, J. Prickaerts, E. Castren, P. C. Casarotto

This study shows that C21, an AT2R agonist, increases TRKB surface levels and enhances BDNF's effect on pTRKB in neurons, reducing freezing time in mice in a BDNF-dependent manner without affecting anxiety.

bioRxiv · Jul 20, 2021Pharmacology & Toxicology

Nitric Oxide Synthase inhibition counteracts the stress-induced DNA methyltransferase 3b expression in the hippocampus of rats

I. de Sousa Maciel, A. J. Sales, P. C. Casarotto, E. Castren, C. Biojone, S. R. L. Joca

This study shows that inhibiting nitric oxide synthase reduces stress-induced DNMT3b expression in rat hippocampus, suggesting a role for NO in stress-related epigenetic changes.

bioRxiv · Aug 6, 2020Pharmacology & Toxicology

Pharmacologically diverse antidepressant drugs disrupt the interaction of BDNF receptor TRKB and the endocytic adaptor AP-2

S. M. Fred, L. Laukkanen, C. Brunello, L. Vesa, H. Goos, I. Cardon, R. Moliner, T. Maritzen, M. Varjosalo, P. C. Casarotto, E. Castren

This study shows that multiple antidepressants disrupt the TRKB:AP2M interaction, affecting TRKB surface expression and BDNF signaling.

bioRxiv · Sep 30, 2019Pharmacology & Toxicology

Inducible nitric oxide synthase (NOS2) knockout mice as a model of trichotillomania

P. C. Casarotto, C. Biojone, K. Montezuma, F. Q. Cunha, S. R. L. Joca, E. Castren, F. S. Guimaraes

This study shows that NOS2 knockout mice exhibit increased barbering behavior and repetitive movements, linked to altered NMDA receptor levels and neuronal morphology, suggesting a role for NOS2 in striatal motor regulation.

bioRxiv · Nov 9, 2016Animal Behavior & Cognition