Author

L. Laukkanen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

E. Castren· 2 shared P. C. Casarotto· 2 shared C. Brunello· 1 shared C. R. A. F. Dinz· 1 shared H. Goos· 1 shared I. Cardon· 1 shared J. Prickaerts· 1 shared L. Vesa· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersPharmacology & Toxicology

E. Castren

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2 papers

Recent·Most cited

Facilitation of TRKB activation by the angiotensin II receptor type-2 (AT2R) agonist C21

L. Laukkanen, C. R. A. F. Dinz, S. Foulquier, J. Prickaerts, E. Castren, P. C. Casarotto

This study shows that C21, an AT2R agonist, increases TRKB surface levels and enhances BDNF's effect on pTRKB in neurons, reducing freezing time in mice in a BDNF-dependent manner without affecting anxiety.

bioRxiv · Jul 20, 2021Pharmacology & Toxicology

Pharmacologically diverse antidepressant drugs disrupt the interaction of BDNF receptor TRKB and the endocytic adaptor AP-2

S. M. Fred, L. Laukkanen, C. Brunello, L. Vesa, H. Goos, I. Cardon, R. Moliner, T. Maritzen, M. Varjosalo, P. C. Casarotto, E. Castren

This study shows that multiple antidepressants disrupt the TRKB:AP2M interaction, affecting TRKB surface expression and BDNF signaling.

bioRxiv · Sep 30, 2019Pharmacology & Toxicology