Histone chaperone HIRA, Promyelocytic Leukemia (PML) protein and p62/SQSTM1 coordinate to regulate inflammation during cell senescence.
N. Dasgupta, X. Lei, C. H. Shi, R. Arnold, M. G. Teneche, K. N. Miller, A. Rajesh, A. Davis, V. Anschau, A. R. Campos, R. Gilson, A. Havas, S. Yin, Z. M. Chua, T. Liu, , P. D. Adams
This study shows HIRA and PML regulate SASP through interactions with p62/SQSTM1 and the cGAS-STING pathway in senescent cells.
bioRxiv · Jun 24, 2023Cell Biology