A. R. Campos

Histone chaperone HIRA, Promyelocytic Leukemia (PML) protein and p62/SQSTM1 coordinate to regulate inflammation during cell senescence.

This study shows HIRA and PML regulate SASP through interactions with p62/SQSTM1 and the cGAS-STING pathway in senescent cells.

ISCA2 inhibition decreases HIF and induces ferroptosis in clear cell renal carcinoma

This study identifies ISCA2 as a target for inhibiting HIF-1/2 and inducing ferroptosis in clear cell renal carcinoma, showing efficacy in xenograft models.

PSGL-1 directs early TCR signaling to repress metabolism and promote T cell exhaustion by modulating the TCF-1/TOX axis in CD8+ T cells.

This study shows PSGL-1 modulates TCF-1/TOX axis to repress metabolism and promote T cell exhaustion in CD8+ T cells, making it a therapeutic target for PD-1/PD-L1 resistant tumors.

Vascular proteome responses precede organ dysfunction in sepsis

This study identifies vascular proteome changes preceding organ dysfunction in sepsis using a murine model and integrative analysis.

Combined Inhibition of AKT and KIT Restores Expression of Programmed Cell Death 4 (PDCD4) in Gastrointestinal Stromal Tumor

This study shows that combining AKT and KIT inhibitors restores PDCD4 expression in GIST cells, leading to cell death, but the combination is less effective in IM-resistant models.

A reference map of the human proinsulin biosynthetic interaction network

This study identifies a conserved proinsulin interactome in human islets, revealing PRDX4's role in proinsulin folding and its inactivation in T2D.