Bisphosphonate drugs have actions outside the skeleton and inhibit the mevalonate pathway in alveolar macrophages
M. J. Rogers, M. A. Munoz, E. K. Fletcher, O. P. Skinner, J. Jurczyluk, E. Kristianto, M. Hodson, S. Sun, F. H. Ebetino, D. R. Croucher, P. M. Hansbro, J. R. Center
This study shows bisphosphonates inhibit the mevalonate pathway in macrophages, enhancing immune responses to bacterial endotoxin in the lung.
bioRxiv · Aug 9, 2021Pharmacology & Toxicology