P. M. Hansbro

Fecal microbial transfer and complex carbohydrates mediate protection against COPD

This study shows that fecal microbial transfer and complex carbohydrates can reduce COPD symptoms in mice and humans, linking gut microbiota to disease progression.

Comparison of commercially available differentiation media on morphology, function, and virus-host interaction in conditionally reprogrammed human bronchial epithelial cells

This study compares two differentiation media for conditionally reprogrammed human bronchial epithelial cells, finding structural and functional differences but no impact on viral infection outcomes.

A subset of CD4+ effector memory T cells limit immunity to pulmonary viral infection and prevent tissue pathology via activation of latent TGFβ

The paper identifies a subset of CD4+ effector memory T cells that limit secondary immune responses to viral re-infection and prevent lung pathology by activating latent TGFβ.

Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients

This paper isolates broadly neutralizing SARS-CoV-2 antibodies from convalescent patients and shows they neutralize emerging variants more effectively than existing monoclonal antibodies.

Single cell RNA-seq identifies inflammation-induced loss of CFTR-expressing airway ionocytes in non-eosinophilic asthma

This study identifies inflammation-induced loss of CFTR-expressing ionocytes in non-eosinophilic asthma using single-cell RNA-seq and confirms it in human and murine models.

Australia as a global sink for the genetic diversity of avian influenza A virus

This study shows Australia acts as a global sink for avian influenza A virus diversity, with isolated circulation and high reassortment, distinct from Northern Hemisphere patterns.

Exposure to the gut microbiota from cigarette smoke-exposed mice exacerbates cigarette smoke extract-induced inflammation in zebrafish larvae

The paper shows that gut microbiota from cigarette smoke-exposed mice worsens inflammation in zebrafish larvae exposed to cigarette smoke extract.

Bisphosphonate drugs have actions outside the skeleton and inhibit the mevalonate pathway in alveolar macrophages

This study shows bisphosphonates inhibit the mevalonate pathway in macrophages, enhancing immune responses to bacterial endotoxin in the lung.

A single dose, BCG-adjuvanted COVID-19 vaccine provides sterilizing immunity against SARS-CoV-2 infection in mice

A BCG-adjuvanted vaccine provides sterilizing immunity against SARS-CoV-2 in mice, with high neutralizing antibody titers and Th1 responses.

Differences in pulmonary innate lymphoid cells are dependent on mouse age, sex and strain

This study examines how mouse age, sex, and strain affect lung innate lymphoid cell (ILC) numbers and surface antigen expression.

SARS-CoV-2 Spike protein promotes hyper-inflammatory response that can be ameliorated by Spike-antagonistic peptide and FDA-approved ER stress and MAP kinase inhibitors in vitro

This study shows that SARS-CoV-2 spike protein induces inflammation and epithelial damage, which can be reduced by an antagonistic peptide and FDA-approved drugs.

Pathophysiological regulation of lung function by the free fatty acid receptor FFA4

This study shows that activating FFA4 reduces airway resistance in mouse models of inflammation and human lung tissue, suggesting it could be a therapeutic target for asthma and COPD.