J. R. Kaspar

Human Saliva Modifies Growth, Biofilm Architecture and Competitive Behaviors of Oral Streptococci

This study shows that human saliva affects growth, biofilm structure, and competitive interactions between oral streptococci species.

Spatial correlations and distribution of competence gene expression in biofilms of Streptococcus mutans

The paper uses two-photon microscopy to study spatial distribution of comX expression in S. mutans biofilms, finding that competence-signaling peptides diffuse efficiently and do not create clustered microenvironments.

Exploring novel probiotic mechanisms of Streptococcus A12 with functional genomics

This study identifies molecular mechanisms by which Streptococcus A12 competes with S. mutans using functional genomics and gene deletion analysis.

Spontaneously Arising Streptococcus mutans Variants With Reduced Susceptibility to Chlorhexidine Display Genetic Defects and Diminished Fitness

This study identifies chlorhexidine-tolerant variants of Streptococcus mutans and finds they have genetic defects and reduced fitness in oral biofilms.

Intracellular signaling through the comRS system in Streptococcus mutans genetic competence

This study shows that S. mutans can activate comX through intracellular positive feedback loops involving ComS/XIP, independent of extracellular signals.

Threshold regulation and stochasticity from the MecA/ClpCP proteolytic system in Streptococcus mutans competence

This study investigates how MecA/ClpCP regulates competence in S. mutans by providing threshold control and stochasticity in comY activation.