R. A. Burne

Heterogeneous lineage-specific arginine deiminase expression within dental microbiome species

The paper investigates ADS operon expression in dental microbiomes using metatranscriptomics and identifies lineage-specific differences in ADS activity between healthy and cavitated teeth.

Genetic Characterization of Glyoxalase Pathway in Oral Streptococci and its Contribution to Interbacterial Competition

This study investigates the glyoxalase pathway in oral streptococci, showing Streptococcus mutans has greater RES tolerance and competitiveness compared to Streptococcus sanguinis.

Glucose PTS Modulates Pyruvate Metabolism, Bacterial Fitness, and Microbial Ecology in Oral Streptococci

This study shows that glucose PTS mutants in oral streptococci alter pyruvate metabolism, enhancing acid tolerance and interspecies interactions, which impacts microbial ecology and dental caries.

Spontaneous Mutants of Streptococcus sanguinis with Defects in the Glucose-PTS Show Enhanced Post-Exponential Phase Fitness

The paper identifies glucose-PTS mutants in Streptococcus sanguinis that show enhanced survival in acidic conditions and improved inhibition of Streptococcus mutans.

Mutanofactin promotes bacterial adhesion and biofilm formation of cariogenic Streptococcus mutans

The paper identifies mutanofactin-697, a secondary metabolite from S. mutans, which promotes biofilm formation by increasing bacterial hydrophobicity and adhesion.

Amino Sugars Reshape Interactions between Streptococcus mutans and Streptococcus gordonii.

This study investigates how amino sugars like GlcN and GlcNAc affect gene expression and interactions between Streptococcus mutans and Streptococcus gordonii, revealing significant transcriptomic changes and metabolic reprogramming.

Repurposing the Streptococcus mutans CRISPR-Cas9 System to Understand Essential Gene Function

The paper develops a CRISPR interference tool for Streptococcus mutans to study essential genes, identifying growth defects and phenotypes in 77% of targeted strains.

Exploring novel probiotic mechanisms of Streptococcus A12 with functional genomics

This study identifies molecular mechanisms by which Streptococcus A12 competes with S. mutans using functional genomics and gene deletion analysis.

Carbohydrate and PepO control bimodality in competence development by Streptococcus mutans

This study identifies how carbohydrate source and PepO modulate bimodal comX expression in Streptococcus mutans, revealing mechanisms controlling competence development.

Spontaneously Arising Streptococcus mutans Variants With Reduced Susceptibility to Chlorhexidine Display Genetic Defects and Diminished Fitness

This study identifies chlorhexidine-tolerant variants of Streptococcus mutans and finds they have genetic defects and reduced fitness in oral biofilms.

Amino Sugars Modify Antagonistic Interactions between Commensal Oral Streptococci and Streptococcus mutans

This study shows amino sugars like GlcNAc and GlcN enhance the competitiveness of commensal oral streptococci against S. mutans, reducing its viability in co-cultures and biofilms.

Essential Roles of the sppRA Fructose-Phosphate Phosphohydrolase Operon in Carbohydrate Metabolism and Virulence Expression by Streptococcus mutans

This paper identifies the sppRA operon in Streptococcus mutans, showing it regulates fructose metabolism and virulence by modulating fructose-1-phosphate levels and stress responses.

Intracellular signaling through the comRS system in Streptococcus mutans genetic competence

This study shows that S. mutans can activate comX through intracellular positive feedback loops involving ComS/XIP, independent of extracellular signals.

Species Designations Belie Phenotypic and Genotypic Heterogeneity in Oral Streptococci

The paper examines phenotypic and genotypic variability in oral Streptococcus isolates, finding poor correlation between genotype and phenotype across species.

Preferred hexoses influence long-term memory and induction of lactose catabolism by Streptococcus mutans

This study shows that Streptococcus mutans exhibits long-term memory effects in lactose catabolism based on prior exposure to glucose or fructose, with implications for bacterial persistence and virulence.

Threshold regulation and stochasticity from the MecA/ClpCP proteolytic system in Streptococcus mutans competence

This study investigates how MecA/ClpCP regulates competence in S. mutans by providing threshold control and stochasticity in comY activation.

Intercellular communication via the comX-Inducing Peptide (XIP) of Streptococcus mutans

This study demonstrates that XIP from Streptococcus mutans functions as an intercellular signal, showing diffusibility and signaling without cell-to-cell contact, with cell lysis enhancing its release.